Replacing Finasteride pills with Finasteride lotion? More information

10 July, 2019 10:44

Moving away from Oral Finasteride? Here are some excellent reasons.

At our clinic our Drs have decided to halt offering oral finasteride in favor of a Finasteride mixed with Minoxidil lotion.

The decision came after visiting FUE Europe meeting 2019 in Manchester where many Drs presented their cases and experiences regarding topical finasteride.

The results are overwhelming in favor of using a topical Finasteride solution mixed with Minoxidil. No possible averse effects that are linked to oral Finasteride have been detected so far.

Our Drs have decided to favor a version of 0.5% finasteride and 5% Minoxidil.

An example of a results, fully documented by one of our patients can be seen below (after using about 10 months, daily 2 applications)

Here a nice study comparing study between a lotion containing 0.25 % finasteride and 3% Minoxidil vs a lotion only containing 3% Minoxidil.

 Abstract

Background

The synergism of combined use between oral finasteride and topical minoxidil has been established in treating androgenetic alopecia among men. However, the concern regarding adverse effects of finasteride use has been rising.

Objective

To compare the efficacy and safety of topical solution of 0.25% finasteride admixed with 3% minoxidil vs. 3% minoxidil solution in men with androgenetic alopecia.

Methods

Forty men aged 18–60 years with androgenetic alopecia were randomized to 24 weeks of treatment with a finasteride/minoxidil or minoxidil solution twice daily. Primary efficacy endpoint was the change from baseline in hair density and hair diameter at week 24. Secondary endpoints included global photographic assessment by treatment‐blinded investigators and subjects. Changes in plasma dihydrotestosterone levels and adverse events were recorded.

Results

At week 24, the combined solution of finasteride and minoxidil was significantly superior to minoxidil alone in improvements of hair density, hair diameter and global photographic assessment (all P < 0.05). About 90% of patients treated with the combined solution experienced moderate to marked improvement. The combined solution also had minimal effect on plasma dihydrotestosterone levels, approximately 5% reduction. There were also no systemic adverse events reported by patients in both groups.

Conclusion

Treatment with topical solution of 0.25% finasteride admixed with 3% minoxidil was significantly superior to 3% minoxidil solution for promoting hair growth in male androgenetic alopecia, and well tolerated.

 

https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15171